To factor the given expression, we will use the difference of squares pattern.
a^2- b^2=( a- b)( a+ b)
Let's write it in a^2-b^2 form and factor.
x^(16)-81 & = ( x^8)^2- 9^2
&=( x^8- 9)( x^8+ 9)
Notice that x^8-9 is also a difference of squares. We need to apply the technique one more time.
x^8-9 & = ( x^4)^2- 3^2
&=( x^4- 3)( x^4+ 3)
Since 3 is not a perfect square, (x^4-3) is not a difference of squares. We will now replace x^8-9 with its factored form.
x^(16)-81 & = (x^8-9)(x^8+9)
& = (x^4-3)(x^4+3)(x^8+9)